A central challenge in cancer care is to ensure that therapeutic compounds reach their targets. One approach is to use enzyme-responsive biomaterials, which reconfigure in response to endogenous enzymes that are overexpressed in diseased tissues, as potential site-specific anti-tumoral therapies. Here we report peptide micelles that upon MMP-9 catalyzed hydrolysis reconfigure to form fibrillar nanostructures. […]
Classification trees are attractive for practical applications because of their comprehensibility. However, the literature on the parameters that influence their comprehensibility and usability is scarce. This paper systematically investigates how tree structure parameters (the number of leaves, branching factor, tree depth) and visualisation properties influence the tree comprehensibility. In addition, we analyse the influence of […]
Adaptive filters embedded in a user-friendly virtual instrument (VI) for signal denoising are proposed in the paper. The filters are based on the local polynomial approximation (LPA) and equipped with the improved intersection of confidence intervals (ICI) rule, known as the relative intersection of confidence intervals (RICI) rule, in order to achieve adaptivity to high […]
As primary navigational mean, Electronic Chart Display and Information System became an inevitable tool and decision-making assistance. ECDIS implementation entails several issues, ranging from proper understanding, education, training, handling and acceptance of this, still relatively new, technology. The navigational tool has changed, however traditional navigational skills remain, or at least, they should sustain. ECDIS EHO […]
Software defect prediction research relies on data that must be collected from otherwise separate repositories. To achieve greater generalization of the results, standardized protocols for data collection and validation are necessary. This paper presents an exhaustive survey of techniques and approaches used in the data collection process. It identifies some of the issues that must […]
We demonstrate an in situ ultrasonic approach to influence self-assembly across the supramolecular to micron length scales, showing enhancement of supramolecular interactions, chirality and orientation, which depends on the peptide sequence and solvent environment. This is the first successful demonstration of using oscillating pressure waves to generate anisotropic organo- and hydrogels consisting of oriented tripeptides structures.
In the area of human–computer interaction, contemporary head tracking systems are often used as camera-based mouse emulators. While head movement detection provides the basis for related mouse shifting and positioning, standard click actions are usually emulated using stillness counter techniques such as Dwell Click (DC). However, these techniques can be a source of enlarged interaction […]
Peptides that self-assemble into nanostructures are of tremendous interest for biological, medical, photonic and nanotechnological applications. The enormous sequence space that is available from 20 amino acids probably harbours many interesting candidates, but it is currently not possible to predict supramolecular behaviour from sequence alone. Here, we demonstrate computational tools to screen for the aqueous […]
Phenylacetyl-peptide amphiphiles were designed, which upon cleavage by a disease-associated enzyme reconfigure from micellar aggregates to fibres. Upon this morphological change, a doxorubicin payload could be retained in the fibres formed, which makes them valuable carriers for localised formation of nanofibre depots for slow release of hydrophobic anticancer drugs.
Classic navigation using navigational paper charts is being replaced with ECDIS systems, and starting as from 2018, a complete transition to the PLECDIS system as the primary navigational system (eng. Paper – Less Electronic Chart and Display Information System – possessing information system and the display of electronic charts without the obligation of possessing paper […]