Random peptide libraries that cover large search spaces are often used for the discovery of new binders, even when the target is unknown. To ensure an accurate population representation, there is a tendency to use large libraries. However, parameters such as the synthesis scale, the number of library members, the sequence deconvolution and peptide structure […]
Research Papers
Local-Entropy Based Approach for X-Ray Image Segmentation and Fracture Detection
The paper proposes a segmentation and classification technique for fracture detection in X-ray images. This novel rotation-invariant method introduces the concept of local entropy for de-noising and removing tissue from the analysed X-ray images, followed by an improved procedure for image segmentation and the detection of regions of interest. The proposed local Shannon entropy was […]
Support Vector Machine State Estimation
The power system state estimator based on the support vector machine (SVM) and the weighted least squares (WLS) method is presented in the paper. The WLS provides state estimations necessary for creating SVM model which is then used for state estimation. The developed algorithm was tested on the IEEE systems, and the performance indicators were […]
The Influence of Feature Representation of Text on the Performance of Document Classification
In this paper we perform a comparative analysis of three models for a feature representation of text documents in the context of document classification. In particular, we consider the most often used family of bag-of-words models, the recently proposed continuous space models word2vec and doc2vec, and the model based on the representation of text documents […]
ECDIS transitional period completion: Analyses, observations and findings
During the past three decades, the Electronic Chart Display and Information System (ECDIS) evolved from its initial purpose to a complex navigation support tool. The transition from paper to electronic charts represents a substantial step in navigation, contributing to the reduction of the navigator’s workload, ease of execution of navigational tasks and integrated information and […]
Customizing morphology, size, and response kinetics of matrix metalloproteinase-responsive nanostructures by systematic peptide design
Overexpression and activation of matrix metalloproteinase-9 (MMP-9) is associated with multiple diseases and can serve as a stimulus to activate nanomaterials for sensing and controlled release. In order to achieve autonomous therapeutics with improved space-time targeting capabilities, several features need to be considered beyond the introduction of an enzyme-cleavable linker into a nanostructure. We introduce […]
“Old Economy“ Restrictions in the Digital Market for Services
Freedom to provide services is one of the cornerstones of the EU internal market. Facilitated by the digital technologies, new and innovative service markets are emerging. However, innovations often bump into existing obstacles. Whether constrained by inadequate regulatory environment, or opposition from existing service providers in the market, the fact remains that ‘old economy’ is […]
Design and Implementation of Anonymized Social Network-based Mobile Game System for Learning Mathematics
Group work and student collaboration during problem solving sessions are teaching methods which positively affect learning outcomes and socialisation. It is extremely complex to find a way of applying these methods to make them appropriate for and interesting to the new digital generation of students. This paper proposes a model which enables social network collaboration […]
Adaptive State Estimator With Intersection of Confidence Intervals Based Preprocessing
The paper presents an effective solution for improving power system state estimation performance by applying the intersection of confidence intervals (ICI) algorithm, a state-of-the-art adaptive signal processing technique used in signal denoising. Since many power utilities worldwide still run state estimators based on the weighed least squares (WLS) algorithm using supervisory control and data acquisition […]
Analytical implementation of Roe solver for two-layer shallow water equations with accurate treatment for loss of hyperbolicity
A new implementation of the Roe scheme for solving two-layer shallow-water equations is presented in this paper. The proposed A-Roe scheme is based on the analytical solution to the characteristic quartic of the flux matrix, which is an efficient alternative to a numerical eigensolver. Additionally, an accurate method for maintaining the hyperbolic character of the governing system […]
