Energy efficiency of the wireless sensor network (WSN) is one of the dominating issues in the non-stop table grapes cold chain monitoring. The aim of this paper is to propose an energy-efficient sensing method for the non-stop cold chain management of table grapes in order to reduce the average energy consumption of WSN devices and improve the operation and transmission efficiency of WSN, and finally strengthen the transparency, traceability and stabilization in non-stop cold chain monitoring. The energy-efficient sensing in non-stop cold chain monitoring was realized by combining the WSN and the CS transmission mode for the sensor data acquisition and transmission. According to the comprehensive analysis of the environmental performance, the CS performance, the energy consumption of WSN devices, the transmission efficiency and economic performance in actual cold chain of table grapes, the WSN with CS transmission mode could have the sensor data been transmitted with relatively few sampling amount and reconstructed with high accuracy and efficiency. The proposed energy-efficient sensing method could be extended for the non-stop cold chain monitoring applications to improve their energy, operation and transmission efficiency.